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Title: | When serendipity knocks on the door: Synthesis and Physicochemical Characterization of 7-Chloro-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidin-5-one |
Authors: | Carmona-Vargas, Christian C. Ellena, Javier D’Vries, Richard F. Chaur, Manuel N. |
Keywords: | Chlorination Serendipity Thiazolopyrimidine Thiobarbituric acid |
Issue Date: | 19-Mar-2019 |
Publisher: | Sociedade Brasileira de Quimica |
Abstract: | Herein, we present the serendipitous obtaining of 7-chloro-2,3-dihydro-5H-thiazolo [3,2-a]pyrimidin-5-one in 40% yield by using POCl3 and a thiobarbituric acid derivative. The thiazolopyrimidine derivative was characterized by 1H nuclear magnetic resonance (NMR), UV-Vis, and Fourier transform infrared (FTIR) spectroscopy. Additionally, the structure was confirmed by single crystal X-ray diffraction, where it was found that the compound crystallizes in the P-1 triclinic space group with two conformeric molecules of 7-chloro-2,3-dihydro-5H-thiazolo [3,2-a]pyrimidin-5-one by asymmetric unit. Also, from the structural data was studied the supramolecular interactions using Hirshfeld surface analysis and 2D fingerprint plots. © 2019 Sociedade Brasileira de Química |
URI: | https://repository.usc.edu.co/handle/20.500.12421/2050 |
ISSN: | 01035053 |
Appears in Collections: | Artículos Científicos |
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File | Description | Size | Format | |
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When serendipity knocks on the door Synthesis and Physicochemical Characterization of 7-Chloro-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidin-5-one.pdf | 2.03 MB | Adobe PDF | View/Open |
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