Expresión proteica de metaloproteinasa 2 en el riñón de rata durante la gestación en condición de obesidad

Abstract

An epidemiological interest group within the obese community is made up of pregnant women or women of childbearing age (who account for the highest percentage of obese people worldwide) this is because during pregnancy, the physiological changes of the it assume a certain susceptibility from several systems to obesity. One of the systems most affected by this is the renal system. Several authors have found a relationship between obesity and renal pathology in conditions such as generalized or segmental glomerulosclerosis, diabetic or hypertensive nephropathy. These diseases have in common that they develop from an inflammatory and fibrotic process, which originates in the context of the imbalance between the deposit and the degradation of the extracellular matrix collagen. And on this balance, Metalloproteinase 2 plays a fundamental role. However, the relationship between gestational obesity, maternal renal disease and protein expression of MMP-2 has not been referenced. The present study relates these aspects using a murine biomodel, forming a control group and an obese group, in a state of pregnancy, who were tested for inhumohistochemistry in three representative states of the three trimesters of pregnancy, to then determine statistically their behavior and relationship.