“Síntesis, caracterización y análisis estructural de metalofármacos a partir de metales de transición y biguanida como posible tratamiento antidiabético”

Abstract

The synthesis and characterization of a series of coordination compounds of Cu (II), Zn (II) and Fe (II) was performed with metformin hydrochloride, the biguanide most commercially used for the treatment of type II diabetes mellitus, and the co-ligand1,10-phenanthroline in order to potentiate the therapeutic effect of biguanide. These compounds were characterized by spectroscopic techniques such as IR spectroscopy, thermogravimetric analysis, and single crystal X-ray diffraction. It was possible to characterize the compound with formula [Zn(C4H12N5)Cl3], which crystallized in the monoclinic crystalline system and space group P21/c; it was also possible to characterize the compound [Cu(μ-CI)(C4H11N5)Cl]2 , which crystallizes in the monoclinic crystalline system and space group P21/n. Finally, the compound with formula [Fe(C12H8N2)3]Cl2 was obtained, which is located in the tetragonal crystalline system and in the space group I41/a