Evaluación de la capacidad inhibitoria de extractos de curuba y moléculas bioactivas sobre el crecimiento de mycobacterium smegmatis mc2155.

Abstract

The intrinsic resistance that mycobacteria show to some disinfectants and antibiotics makes them a growing public health problem. Due to the fact that natural products and their derivatives have been shown to be a source of new antimicrobials, the effectiveness of hexanic, ethanolic and methanolic extracts of cascara and pulp of the fruit of the curuba (Passiflora mollisima) and some chalcone molecules synthesized by the Research Group of Heterocyclic Compounds of the Universidad del Valle (Colombia), on the growth of Mycobacterium smegmatis mc2155. The results showed that the hexanic extract of peel and a chalcone molecule, were able to inhibit the growing mycobacterium at concentrations of 1 mg/ml and 100 μM, respectively. This demonstrates the potential of curuba, to obtain molecules that, like the chalcones, serve as the basis for obtaining and designing new drugs.