Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/20.500.12421/4522
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dc.contributor.authorMora Vargas, Jorge Andrés-
dc.contributor.authorOrduña Ortega, Julieth-
dc.contributor.authorCorreia Dos Santos, Maitê Bernardo-
dc.contributor.authorMetzker, Gustavo-
dc.contributor.authorGomes, Eleni De Barros-
dc.contributor.authorBoscolo, Maurício-
dc.date.accessioned2020-10-23T22:21:16Z-
dc.date.available2020-10-23T22:21:16Z-
dc.date.issued2020-02-19-
dc.identifier.issn0008-6215-
dc.identifier.urihttp://repository.usc.edu.co/handle/20.500.12421/4522-
dc.description.abstractDescribed are the development of a new synthetic method using ultrasonic irradiation and sodium methoxide as catalyst for a series of pyridinic sucrose esters (py-SEs), derived from transesterification of sucrose with picolinic, nicotinic and isonicotinic methyl esters. The reaction was optimized using a 32 x 2 experimental design, the reaction time, temperature and sucrose: methyl ester molar ratio being evaluated. The method proved to be efficient for obtaining monosubstituted esters (≥83%) with high methyl ester consumption (≥79%). The monosubstituted py-SEs were isolated by semipreparative HPLC, characterized by high-resolution mass spectrometry, calorimetry, vibrational spectroscopy, and 1H and 13C NMR. The py-SEs were tested against E. coli, S. aureos, and P. aeruginosa bacteria with minimum inhibitory concentration values equal or inferior to the reference drugs for both E. coli and P. aeruginosa.en_US
dc.language.isoenen_US
dc.publisherElsevier Ltden_US
dc.subjectAcoustic cavitationen_US
dc.subjectAntibacterial activityen_US
dc.subjectHomogeneous catalysisen_US
dc.subjectPyridinic methyl estersen_US
dc.subjectUcrose estersen_US
dc.titleA new synthetic methodology for pyridinic sucrose esters and their antibacterial effects against Gram-positive and Gram-negative strainsen_US
dc.typeArticleen_US
Appears in Collections:Artículos Científicos

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