Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/20.500.12421/4530
Title: Multiple Reversible Dynamics of Pyrimidine Based Acylhydrazones
Authors: Arango, Alejandra M.
Wist, Julien
Ellena, Javier Alcides
D'Vries, Richard Fernando
Chaur, Manuel N.
Keywords: Acylhydrazone
Configurational isomerization
Conformational isomerism
Dynamic chemistry
Issue Date: 8-May-2020
Publisher: Wiley-VCH Verlag
Abstract: We employed (Z)‐N'‐[phenyl(pyrimidin‐2‐yl)methylene]nicotinohydrazide (2) and (Z)‐4‐(dimethylamino)‐N'‐[phenyl(pyrimidin‐2‐yl)methylene]benzohydrazide (3) as cores of dynamic chemical systems whose different states are modulated, in a reversible fashion, through specific physical and chemical stimuli. The structure of the compounds was determined by Nuclear Magnetic Resonance (NMR) techniques (1D and 2D) and confirmed by single‐crystal X‐ray diffraction. By Variable temperature (VT) 1H NMR experiments and DFT calculations, the conformational isomerism of 2 was studied and added as an additional input for the dynamic system. Additionally, 2 exhibits configurational E/Z isomerization mediated by pH variations and UV light. On the other hand, configurational isomerism locks an unlocks a tridentate pocket for metal cation coordination in both 2 and 3. All the different dynamic states configurational/conformational isomerism and locked and unlocked coordination constitute a development in the field of systems of multiple dynamics suitable for molecular machines.
URI: http://repository.usc.edu.co/handle/20.500.12421/4530
ISSN: 1434-193X
Appears in Collections:Artículos Científicos

Files in This Item:
File Description SizeFormat 
Multiple Reversible Dynamics of Pyrimidine Based Acylhydrazones.png101.54 kBimage/pngView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.