Please use this identifier to cite or link to this item:
http://localhost:8080/xmlui/handle/20.500.12421/471
Title: | When Serendipity Knocks on the Door: Synthesis and Physicochemical Characterization of 7-Chloro-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidin-5-one |
Authors: | Carmona-Vargas, Christian C. Ellena, Javier D’Vries, Richard F. Chaur, Manuel N. |
Keywords: | chlorination thiobarbituric acid serendipity thiazolopyrimidine |
Issue Date: | 2019 |
Publisher: | Journal of the Brazilian Chemical Society |
Abstract: | Herein, we present the serendipitous obtaining of 7-chloro-2,3-dihydro-5H-thiazolo [3,2-a]pyrimidin-5-one in 40% yield by using POCl3 and a thiobarbituric acid derivative. The thiazolopyrimidine derivative was characterized by 1H nuclear magnetic resonance (NMR), UV-Vis, and Fourier transform infrared (FTIR) spectroscopy. Additionally, the structure was confirmed by single crystal X-ray diffraction, where it was found that the compound crystallizes in the P-1 triclinic space group with two conformeric molecules of 7-chloro-2,3-dihydro-5H-thiazolo [3,2-a]pyrimidin-5-one by asymmetric unit. Also, from the structural data was studied the supramolecular interactions using Hirshfeld surface analysis and 2D fingerprint plots. |
URI: | https://repository.usc.edu.co/handle/20.500.12421/471 |
ISSN: | 1678-4790 |
Appears in Collections: | Producción Científica |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
When_Serendipity_Knocks_on_the_Door_Synthesis_and_.pdf | 2.1 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.